Yeah I'm getting this too, and now if I put into legacy interface with EOC which fixed the banking problem for me it now isn't using the hotkey (1) it just clicks it on the action bar which is okay until it misses the icon (which happens after about 5 inventories) and does nothing.
When it is...
I had this problem, I put runescape on legacy mode (combat and interface) then turned graphics mode to fixed which didn't change until I then turned legacy combat off.
P.S. you have to right click the 'all' chat option to toggle the always on chat mode then hotkeys work
