[navarrete18]

curious what do you need to set up to make combo runes?

 

[based]

curious what do you need to set up to make combo runes?

Just change the runes you want to craft to the combination runes.
As for your inventory setup, you can have a look here

Guardians of the Rift/Strategies - OSRS Wiki

Although the Guardians of the Rift minigame can be completed with varying levels and equipment, the general strategy remains consistent. Those without access to the larger essence pouches may have to convert more guardian essence and make more frequent trips through the runic altars.

oldschool.runescape.wiki

Guardians of the Rift/Strategies - OSRS Wiki

Although the Guardians of the Rift minigame can be completed with varying levels and equipment, the general strategy remains consistent. Those without access to the larger essence pouches may have to convert more guardian essence and make more frequent trips through the runic altars.

oldschool.runescape.wiki